Interrelation between plasma membrane calcium ATPase-1 and inflammatory mediators expression in gingival tissue depending on severity of periodontitis
Yoon Da-Le, 박수연, 김용건, 이재목,
소속 상세정보
( Yoon Da-Le ) - Kyungpook National University School of Dentistry Department of Periodontics
박수연 ( Park Su-Yeon ) - Kyungpook National University School of Dentistry Department of Periodontics
김용건 ( Kim Yong-Gun ) - Kyungpook National University School of Dentistry Department of Periodontics
이재목 ( Lee Jae-Mok ) - Kyungpook National University School of Dentistry Department of Periodontics
Abstract
We investigated the effects of severity of periodontitis on inflammation progression by observing the expression and interaction of inflammatory mediators such as plasma membrane calcium ATPase (PMCA)-1, interleukin (IL)-11, and leukemia inhibitory factor (LIF), which are involved in bone metabolism, in healthy tissues and tissues according to the severity of inflammation. The aim of this study was to investigate the effect of these factors on periodontal tissue destruction. Gingival tissue specimens were collected from patients with periodontal disease and healthy individuals, at the Department of Periodontics, Kyungpook National University Dental Hospital. Specimen was recruited from the patients were obtained during periodontal surgery. Western blotting was used to observe the expression of PMCA-1, IL-11, and LIF in each tissue. The expression of PMCA-1 was increased in periodontitis groups and was highest in severe periodontitis group. IL-11 expression was increased in periodontitis groups and was highest in severe periodontitis group. LIF expression was decreased in periodontitis groups and was highest in normal group. There were a statistically significant difference between normal and moderate group, normal and severe periodontitis group, and moderate and severe periodontitis group. In conclusion, PMCA-1, IL-11, and LIF appear to be associated with the severity of chronic periodontitis. These factors may influence each other.
키워드
Chronic periodontitis; Inflammation; Interleukin; Leukemia inhibitory factor; Plasma membrane calcium ATPase
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